Open Access Articles- Top Results for Pyoderma gangrenosum

Pyoderma gangrenosum

Pyoderma gangrenosum
File:Crohnie Pyoderma gangrenosum.jpg
Pyoderma gangrenosum on the leg of a patient with Crohn's disease.
Classification and external resources
ICD-10 L88
ICD-9 686.01
DiseasesDB 11064
eMedicine article/1123821
NCI Pyoderma gangrenosum
Patient UK Pyoderma gangrenosum
MeSH D017511

Pyoderma gangrenosum is a condition that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.

The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.[1]


There are two main types of pyoderma gangrenosum:[1]

  • the 'typical' ulcerative form, which occurs in the legs
  • an 'atypical' form that is more superficial and occurs in the hands and other parts of the body

Other variations are:[2]


Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.[1] For instance, ulcerative colitis, rheumatoid arthritis, and multiple myeloma (MM) sufferers have the condition. It can also be part of a syndrome, for instance in PAPA syndrome. Major and minor trauma are also believed to play a role.[5]


The following are conditions commonly associated with pyoderma gangrenosum:[6]

Also granulomatosis with polyangiitis[8]


First-line therapy for disseminated or localized instances of pyoderma gangrenosum is systemic treatment by corticosteroids and cyclosporine. Topical application of clobetasol, mupirocin, and gentamicin alternated with tacrolimus can be effective.

Papules that begin as small "spouts" can be treated with Dakins Solution to prevent infection and entire wounds cluster also benefit from this disinfectant. Wet to dry applications of Dakins can defeat spread of interior infection. Heavy drainage can be offset with Coban dressings. Grafting is not recommended due to tissue necrosis.

If ineffective, alternative therapeutic procedures include systemic treatment with corticosteroids and mycophenolate mofetil; mycophenolate mofetil and cyclosporine; tacrolimus; thalidomide; infliximab; or plasmapheresis.[9]

See also


  1. ^ a b c Jackson, J Mark; Callen, Jeffrey P (April 23, 2012). Elston, Dirk M, ed. "Pyoderma Gangrenosum". Emedicine. 
  2. ^ Brooklyn, T.; Dunnill, G; Probert, C (2006). "Diagnosis and treatment of pyoderma gangrenosum". BMJ 333 (7560): 181–4. PMC 1513476. PMID 16858047. doi:10.1136/bmj.333.7560.181. 
  3. ^ Shankar, S.; Sterling, J. C.; Rytina, E. (2003). "Pustular pyoderma gangrenosum". Clinical and Experimental Dermatology 28 (6): 600–3. PMID 14616824. doi:10.1046/j.1365-2230.2003.01418.x. 
  4. ^ Langan, Sinead M.; Powell, Frank C. (2005). "Vegetative pyoderma gangrenosum: A report of two new cases and a review of the literature". International Journal of Dermatology 44 (8): 623–9. PMID 16101860. doi:10.1111/j.1365-4632.2005.02591.x. 
  5. ^ Rashid, RM (2008). "Seat belt pyoderma gangrenosum: Minor pressure as a causative factor". Journal of the European Academy of Dermatology and Venereology 22 (10): 1273–4. PMID 18837131. doi:10.1111/j.1468-3083.2008.02626.x. 
  6. ^ Brooklyn, Trevor; Giles Dunnill; Chris Probert (2006). "Diagnosis and treatment of pyoderma gangrenosum". British Medical Journal 333: 181–184. PMC 1513476. PMID 16858047. doi:10.1136/bmj.333.7560.181. Retrieved 31 December 2013. 
  7. ^ Tendas, Andrea; Niscola P, Barbati R, Abruzzese E, Cuppelli L, Giovannini M, Scaramucci L, Fratoni S, Ales M, Neri B, Morino L, Dentamaro T, De Fabritiis P. (May 2011). "Tattoo related pyoderma/ectyma gangrenous as presenting feature of relapsed acute myeloid leukaemia: an exceptionally rare observation.". Injury 42 (5): 546–7. doi:10.1016/j.injury.2010.08.014. 
  8. ^ Ponniah, I.; Shaheen, Ahmed; Shankar, K.A.; Kumaran, M.G. (2005). "Wegener's granulomatosis: The current understanding". Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 100 (3): 265–70. PMID 16122651. doi:10.1016/j.tripleo.2005.04.018. 
  9. ^ Reichrath, Jörg; Bens, Guido; Bonowitz, Anette; Tilgen, Wolfgang (2005). "Treatment recommendations for pyoderma gangrenosum: An evidence-based review of the literature based on more than 350 patients". Journal of the American Academy of Dermatology 53 (2): 273–83. PMID 16021123. doi:10.1016/j.jaad.2004.10.006. 

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