Open Access Articles- Top Results for Pyrithyldione


Systematic (IUPAC) name
Clinical data
Trade names Benedorm, Didropyridine, Dihydroprylone, Persedon, Presidon, Pyridion, Pyridione, Pyrithyldion, Pyrithyldione, Tetridin, Tetridine
77-04-3 7pxN
PubChem CID 4994
ChemSpider 4820 7pxY
UNII 8AB20823CK 7pxY
KEGG D07329 7pxY
ChEMBL CHEMBL1722501 7pxN
Chemical data
Formula C9H13NO2
167.205 g/mol
 14pxN (what is this?)  (verify)

Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949.[1] An improved method of manufacture was patented by Roche in 1959.[2] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates.[3] Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect.[4][5]

See also


  1. ^ Becker, E. L.; Fabing, H. D.; Hawkins, J. R. (1949). "Presidon; A New Sedative-Hypnotic". Christ Hospital Medical Bulletin 2 (4): 80–84. PMID 18144514.  edit
  2. ^ US patent 3019230, Hinderling, R.; Lutz, A. H. & Schnider, O., "Method for the preparation of 2,4-dioxo-tetrahydropyridines", issued 1962-01-30, assigned to Hoffmann-La Roche 
  3. ^ Pribilla, O. (1956). "Zur Toxikologie des Persedons". Archiv für Toxikologie 16 (1): 34–49. doi:10.1007/BF00577351.  edit
  4. ^ Ibáñez, L.; Ballarín, E.; Pérez, E.; Vidal, X.; Capellà, D.; Laporte, J. R. (2000). "Agranulocytosis Induced by Pyrithyldione, a Sedative Hypnotic Drug". European Journal of Clinical Pharmacology 55 (10): 761–764. PMID 10663456. doi:10.1007/s002280050011.  edit
  5. ^ Covner, A. H.; Halpern, S. L. (1950). "Fatal Agranulocytosis Following Therapy with Presidon (3,3-Diethyl-2,4-Dioxotetrahydropyridine), a New Sedative Hypnotic Agent". New England Journal of Medicine 242 (2): 49–52. PMID 15399031. doi:10.1056/NEJM195001122420203.  edit

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