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Open Access Articles- Top Results for RFX2

RFX2

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Identifiers
SymbolsRFX2 ; FLJ14226
External IDsOMIM142765 MGI106583 HomoloGene30980 GeneCards: RFX2 Gene
RNA expression pattern
File:PBB GE RFX2 208031 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez599019725
EnsemblENSG00000087903ENSMUSG00000024206
UniProtP48378P48379
RefSeq (mRNA)NM_000635NM_009056
RefSeq (protein)NP_000626NP_033082
Location (UCSC)Chr 19:
5.99 – 6.2 Mb
Chr 17:
56.78 – 56.83 Mb
PubMed search[1][2]

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[2]

References

  1. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics 13 (4): 1307–10. PMID 1505960. doi:10.1016/0888-7543(92)90052-T. 
  2. ^ a b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)". 

Further reading

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External links


Template:Gene-19-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.