Open Access Articles- Top Results for RFX4


SymbolsRFX4 ; NYD-SP10
External IDsOMIM603958 MGI1918387 HomoloGene31119 GeneCards: RFX4 Gene
RefSeq (mRNA)NM_001206691NM_001024918
RefSeq (protein)NP_001193620NP_001020089
Location (UCSC)Chr 12:
106.98 – 107.16 Mb
Chr 10:
84.76 – 84.91 Mb
PubMed search[1][2]

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.[1][2][3]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.[3]


  1. ^ Emery P, Durand B, Mach B, Reith W (May 1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res 24 (5): 803–7. PMC 145730. PMID 8600444. doi:10.1093/nar/24.5.803. 
  2. ^ Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y (Jan 2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem 277 (1): 836–42. PMID 11682486. doi:10.1074/jbc.M108638200. 
  3. ^ a b "Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)". 

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