Open Access Articles- Top Results for RHCG


SymbolsRHCG ; C15orf6; PDRC2; RHGK; SLC42A3
External IDsOMIM605381 MGI1888517 HomoloGene32310 IUPHAR: 1200 GeneCards: RHCG Gene
RNA expression pattern
File:PBB GE RHCG 219554 at tn.png
More reference expression data
RefSeq (mRNA)NM_016321NM_019799
RefSeq (protein)NP_057405NP_062773
Location (UCSC)Chr 15:
90 – 90.04 Mb
Chr 7:
79.59 – 79.62 Mb
PubMed search[1][2]

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[1][2]


RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein[4] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.


  1. ^ "Entrez Gene: RHCG Rh family, C glycoprotein". 
  2. ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. PMID 10852913. doi:10.1074/jbc.M003353200. 
  3. ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature 456 (7220): 339–43. PMID 19020613. doi:10.1038/nature07518. 
  4. ^ PDB 3hd6; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. PMC 2906887. PMID 20457942. doi:10.1073/pnas.1003587107. 

Further reading


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