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ROR1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsROR1 ; NTRKR1; dJ537F10.1
External IDsOMIM602336 MGI1347520 HomoloGene3675 IUPHAR: 1845 GeneCards: ROR1 Gene
EC number2.7.10.1
Orthologs
SpeciesHumanMouse
Entrez491926563
EnsemblENSG00000185483ENSMUSG00000035305
UniProtQ01973Q9Z139
RefSeq (mRNA)NM_001083592NM_013845
RefSeq (protein)NP_001077061NP_038873
Location (UCSC)Chr 1:
64.24 – 64.65 Mb
Chr 4:
100.1 – 100.44 Mb
PubMed search[1][2]

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene.[1][2][3] ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

Function

The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.[1] ROR1 is currently under investigation for its role in the metastasis of cancer cells. [4]

ROR1 has recently been shown to be expressed on ovarian cancer stem cell, on which it seems to play a functional role in promoting migration/invasion or spheroid formation in vitro and tumor engraftment in immune-deficient mice. Treatment with a humanized mAb specific for ROR1 (UC-961) could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice. Moreover, such treatment inhibited the growth of tumor xenografts, which in turn had a reduced capacity to engraft immune-deficient mice and were relatively depleted of cells with features of CSC, suggesting that treatment with UC-961 could impair CSC renewal. Collectively, these studies indicate that ovarian CSCs express ROR1, which may be targeted for anti-CSC therapy. [5]


References

  1. ^ a b "Entrez Gene: receptor tyrosine kinase-like orphan receptor 1". 
  2. ^ Masiakowski P, Carroll RD (December 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". J. Biol. Chem. 267 (36): 26181–90. PMID 1334494. 
  3. ^ Reddy UR, Phatak S, Pleasure D (October 1996). "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains". Oncogene 13 (7): 1555–9. PMID 8875995. 
  4. ^ http://www.foxnews.com/health/2013/06/14/stopping-cancer-spread-researchers-identify-protein-that-regulates-cancer/?test=latestnews
  5. ^ Zhang, S; Cui, B; Lai, H; Liu, G; Ghia, EM; Widhopf GF, 2nd; Zhang, Z; Wu, CC; Chen, L; Wu, R; Schwab, R; Carson, DA; Kipps, TJ (2 December 2014). "Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.". Proceedings of the National Academy of Sciences of the United States of America 111 (48): 17266–71. PMID 25411317. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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