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Open Access Articles- Top Results for ROS1

ROS1

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Identifiers
SymbolsROS1 ; MCF3; ROS; c-ros-1
External IDsOMIM165020 MGI97999 HomoloGene2207 IUPHAR: 1840 ChEMBL: 5568 GeneCards: ROS1 Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE ROS1 207569 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez609819886
EnsemblENSG00000047936ENSMUSG00000019893
UniProtP08922Q78DX7
RefSeq (mRNA)NM_002944NM_011282
RefSeq (protein)NP_002935NP_035412
Location (UCSC)Chr 6:
117.61 – 117.75 Mb
Chr 10:
52.05 – 52.2 Mb
PubMed search[1][2]

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.[1][2]

Function

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.[2]

Interactions

ROS1 (gene) has been shown to interact with PTPN6.[3]

References

  1. ^ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics 60 (2): 114–6. PMID 1611909. doi:10.1159/000133316. 
  2. ^ a b "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)". 
  3. ^ Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W et al. (Jan 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". The Journal of Cell Biology 152 (2): 325–34. PMC 2199605. PMID 11266449. doi:10.1083/jcb.152.2.325. 

Further reading

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