Open Access Articles- Top Results for RPS6KA2


SymbolsRPS6KA2 ; HU-2; MAPKAPK1C; RSK; RSK3; S6K-alpha; S6K-alpha2; p90-RSK3; pp90RSK3
External IDsOMIM601685 MGI1342290 HomoloGene100680 IUPHAR: 1529 ChEMBL: 3906 GeneCards: RPS6KA2 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE RPS6KA2 204906 at tn.png
File:PBB GE RPS6KA2 212912 at tn.png
More reference expression data
RefSeq (mRNA)NM_001006932NM_011299
RefSeq (protein)NP_001006933NP_035429
Location (UCSC)Chr 6:
166.82 – 167.32 Mb
Chr 17:
7.17 – 7.3 Mb
PubMed search[1][2]

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.[1][2]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


RPS6KA2 has been shown to interact with MAPK3[3][4] and MAPK1.[3][4]


  1. ^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol 266 (2 Pt 1): C351–9. PMID 8141249. 
  2. ^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2". 
  3. ^ a b Roux, Philippe P; Richards Stephanie A; Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity". Mol. Cell. Biol. (United States) 23 (14): 4796–804. ISSN 0270-7306. PMC 162206. PMID 12832467. doi:10.1128/MCB.23.14.4796-4804.2003. 
  4. ^ a b Zhao, Y; Bjorbaek C; Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 29773–9. ISSN 0021-9258. PMID 8939914. doi:10.1074/jbc.271.47.29773. 

Further reading


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