Open Access Articles- Top Results for RPS6KA3


SymbolsRPS6KA3 ; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; RSK; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2
External IDsOMIM300075 MGI104557 HomoloGene37940 IUPHAR: 1528 ChEMBL: 2345 GeneCards: RPS6KA3 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE RPS6KA3 203843 at tn.png
More reference expression data
RefSeq (mRNA)NM_004586NM_148945
RefSeq (protein)NP_004577NP_683747
Location (UCSC)Chr X:
20.17 – 20.29 Mb
Chr X:
159.21 – 159.37 Mb
PubMed search[1][2]

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.[1][2]


This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.[1]

Clinical significance

Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).[3]


RPS6KA3 has been shown to interact with CREB-binding protein,[4] MAPK1[5][6] and PEA15.[7]


  1. 1.0 1.1 "Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3". 
  2. Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am. J. Physiol. 266 (2 Pt 1): C351–9. PMID 8141249. 
  3. Jacquot S, Zeniou M, Touraine R, Hanauer A (January 2002). "X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1)". Eur. J. Hum. Genet. 10 (1): 2–5. PMID 11896450. doi:10.1038/sj.ejhg.5200738. 
  4. Merienne, K; Pannetier S; Harel-Bellan A; Sassone-Corsi P (October 2001). "Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities". Mol. Cell. Biol. (United States) 21 (20): 7089–96. ISSN 0270-7306. PMC 99884. PMID 11564891. doi:10.1128/MCB.21.20.7089-7096.2001. 
  5. Zhao, Y; Bjorbaek C; Moller D E (November 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 29773–9. ISSN 0021-9258. PMID 8939914. doi:10.1074/jbc.271.47.29773. 
  6. Smith, J A; Poteet-Smith C E; Malarkey K; Sturgill T W (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". J. Biol. Chem. (UNITED STATES) 274 (5): 2893–8. ISSN 0021-9258. PMID 9915826. doi:10.1074/jbc.274.5.2893. 
  7. Vaidyanathan, Hema; Ramos Joe W (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. (United States) 278 (34): 32367–72. ISSN 0021-9258. PMID 12796492. doi:10.1074/jbc.M303988200. 

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