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RPS6KA4

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Identifiers
SymbolsRPS6KA4 ; MSK2; RSK-B
External IDsOMIM603606 MGI1930076 HomoloGene69288 IUPHAR: 1524 ChEMBL: 3125 GeneCards: RPS6KA4 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE RPS6KA4 204632 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez898656613
EnsemblENSG00000162302ENSMUSG00000024952
UniProtO75676Q9Z2B9
RefSeq (mRNA)NM_001006944NM_019924
RefSeq (protein)NP_001006945NP_064308
Location (UCSC)Chr 11:
64.13 – 64.14 Mb
Chr 19:
6.83 – 6.84 Mb
PubMed search[1][2]

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[1][2][3]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]

Interactions

RPS6KA4 has been shown to interact with MAPK14.[1]

References

  1. 1.0 1.1 Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem 273 (45): 29661–29671. PMID 9792677. doi:10.1074/jbc.273.45.29661. 
  2. Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J 17 (15): 4426–4441. PMC 1170775. PMID 9687510. doi:10.1093/emboj/17.15.4426. 
  3. 3.0 3.1 "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4". 

Further reading

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