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RUNX3

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Identifiers
SymbolsRUNX3 ; AML2; CBFA3; PEBP2aC
External IDsOMIM600210 MGI102672 HomoloGene37914 GeneCards: RUNX3 Gene
RNA expression pattern
File:PBB GE RUNX3 204197 s at tn.png
File:PBB GE RUNX3 204198 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez86412399
EnsemblENSG00000020633ENSMUSG00000070691
UniProtQ13761Q64131
RefSeq (mRNA)NM_001031680NM_019732
RefSeq (protein)NP_001026850NP_062706
Location (UCSC)Chr 1:
25.23 – 25.29 Mb
Chr 4:
135.12 – 135.18 Mb
PubMed search[1][2]

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.[1]

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters,[2] and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

In melanocytic cells RUNX3 gene expression may be regulated by MITF.[4]

Knockout mouse

Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.[5]

Interactions

RUNX3 has been shown to interact with TLE1.[6]

See also

References

  1. Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y (February 1995). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization". Genomics 23 (2): 425–32. PMID 7835892. doi:10.1006/geno.1994.1519. 
  2. Levanon D, Eisenstein M, Groner Y (April 1998). "Site-directed mutagenesis supports a three-dimensional model of the runt domain.". J Mol Biol. 277 (3): 509–12. PMID 9533875. doi:10.1006/jmbi.1998.1633. 
  3. "Entrez Gene: RUNX3 runt-related transcription factor 3". 
  4. Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 
  5. Li QL, Ito K, Sakakura C et al. (April 2002). "Causal relationship between the loss of RUNX3 expression and gastric cancer". Cell 109 (1): 113–24. PMID 11955451. doi:10.1016/S0092-8674(02)00690-6. 
  6. Levanon, D; Goldstein R E; Bernstein Y; Tang H; Goldenberg D; Stifani S; Paroush Z; Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. PMC 21685. PMID 9751710. doi:10.1073/pnas.95.20.11590. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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