Open Access Articles- Top Results for threonine kinase

Receptor protein serine/threonine kinase

Receptor protein serine/threonine kinase
EC number
CAS number 146702-86-5
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a receptor protein serine/threonine kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [receptor-protein] <math>\rightleftharpoons</math> ADP + [receptor-protein] phosphate

Thus, the two substrates of this enzyme are ATP and receptor-protein, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this enzyme class is ATP:[receptor-protein] phosphotransferase. Other names in common use include activin receptor kinase, receptor type I serine/threonine protein kinase, receptor type II serine/threonine protein kinase, STK13, TGF-beta kinase, and receptor serine/threonine protein kinase. This enzyme participates in 7 metabolic pathways: mapk signaling pathway, cytokine-cytokine receptor interaction, TGF beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2GOO, 2H62, 2H64, 2HLQ, and 2HLR.


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