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Related to receptor tyrosine kinase

SymbolsRYK ; D3S3195; JTK5; JTK5A; RYK1
External IDsOMIM600524 MGI101766 HomoloGene68287 IUPHAR: 1849 GeneCards: RYK Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE RYK 202853 s at tn.png
File:PBB GE RYK 214172 x at tn.png
File:PBB GE RYK 216976 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001005861NM_001042607
RefSeq (protein)NP_001005861NP_001036072
Location (UCSC)Chr 3:
133.78 – 133.97 Mb
Chr 9:
102.83 – 102.91 Mb
PubMed search[1][2]

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.[1]


The gene encoding mouse RYK was first identified in 1992.[2] Subsequently cDNA encoding the RYK protein have been isolated from the following species.[3]


In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal domain, an extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[3]


  1. ^ "Entrez Gene: RYK RYK receptor-like tyrosine kinase". 
  2. ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. PMC 50648. PMID 1334548. doi:10.1073/pnas.89.24.11818. 
  3. ^ a b Halford, MM, and Stacker, S.A. (2001). "Revelations of the RYK receptor". Bioessays 23 (1): 34–45. PMID 11135307. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. 

Further reading