Reticulocytopenia, or "aplastic crisis", is the medical term for an abnormal decrease of reticulocytes in the body. Reticulocytes are immature red blood cells. Reticulocytopenia may be a result of viral Parvovirus B19 infection, which invades and destroys red blood cell precursors and halts the red cell production. If infection occurs in individuals with sickle cell anemia or spherocytosis, that will lead to incorporation of 2 anemia-induced mechanisms: decrease red cell production and hemolysis. The result is a severe anemia (aplastic crisis) which may require blood transfusion.
- ^ "Sickle Cell Disease - Basic Principles and Clinical Practice" Edited by Stephen H. Embury, Robert P. Hebbel, Narla Mohandas and Martin Steinberg. Copyright 1996 by Lippincott-Raven. Section IV p352.
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