Open Access Articles- Top Results for Retinoblastoma-like protein 2

Retinoblastoma-like protein 2

SymbolsRBL2 ; P130; Rb2
External IDsOMIM180203 MGI105085 HomoloGene4098 GeneCards: RBL2 Gene
RNA expression pattern
File:PBB GE RBL2 212331 at tn.png
File:PBB GE RBL2 212332 at tn.png
More reference expression data
RefSeq (mRNA)NM_005611NM_001282000
RefSeq (protein)NP_005602NP_001268929
Location (UCSC)Chr 16:
53.47 – 53.53 Mb
Chr 8:
91.07 – 91.12 Mb
PubMed search[1][2]

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]


Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]

See also

Further reading



  1. ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765. 
  2. ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32. PMC 39329. PMID 8643454. doi:10.1073/pnas.93.10.4629. 
  3. ^ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493–8. ISSN 0027-8424. PMC 27922. PMID 9724731. doi:10.1073/pnas.95.18.10493. 
  4. ^ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7. ISSN 0008-5472. PMID 10969803. 
  5. ^ Wang, S; Ghosh R N; Chellappan S P (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98. ISSN 0270-7306. PMC 109329. PMID 9819434. 
  6. ^ Meloni, A R; Smith E J; Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. ISSN 0027-8424. PMC 22250. PMID 10449734. doi:10.1073/pnas.96.17.9574. 
  7. ^ Fusco, C; Reymond A; Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368. 
  8. ^ a b Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMC 116074. PMID 9891079. 
  9. ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. ISSN 0890-9369. PMID 8253383. doi:10.1101/gad.7.12a.2366. 
  10. ^ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684. 
  11. ^ Lacy, S; Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085. 
  12. ^ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61. ISSN 0270-7306. PMC 104385. PMID 10330166. 
  13. ^ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.