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Open Access Articles- Top Results for Retinoid X receptor alpha

Retinoid X receptor alpha

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsRXRA ; NR2B1
External IDsOMIM180245 MGI98214 HomoloGene2220 IUPHAR: 610 ChEMBL: 2061 GeneCards: RXRA Gene
RNA expression pattern
File:PBB GE RXRA 202449 s at tn.png
File:PBB GE RXRA 202426 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez625620181
EnsemblENSG00000186350ENSMUSG00000015846
UniProtP19793P28700
RefSeq (mRNA)NM_001291920NM_001290481
RefSeq (protein)NP_001278849NP_001277410
Location (UCSC)Chr 9:
137.21 – 137.33 Mb
Chr 2:
27.68 – 27.76 Mb
PubMed search[1][2]

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.[1]

Function

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors.[2] In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the cytochrome P450 system genes.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Vitamin D Synthesis Pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531". 


Interactions

Retinoid X receptor alpha has been shown to interact with:

See also

References

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  2. "Entrez Gene: RXRA retinoid X receptor, alpha". 
  3. "Retinoic acid receptor RXR-alpha - Homo sapiens (Human)". UniProt. 
  4. Na SY, Choi HS, Kim JW, Na DS, Lee JW (1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. PMID 9812988. doi:10.1074/jbc.273.47.30933. 
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Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.