Open Access Articles- Top Results for Retinoid X receptor gamma

Retinoid X receptor gamma

SymbolsRXRG ; NR2B3; RXRC
External IDsOMIM180247 MGI98216 HomoloGene21373 IUPHAR: 612 ChEMBL: 2004 GeneCards: RXRG Gene
RNA expression pattern
File:PBB GE RXRG 205954 at tn.png
More reference expression data
RefSeq (mRNA)NM_001256570NM_001159731
RefSeq (protein)NP_001243499NP_001153203
Location (UCSC)Chr 1:
165.37 – 165.41 Mb
Chr 1:
167.6 – 167.64 Mb
PubMed search[1][2]

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[1][2]


This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

See also


Retinoid X receptor gamma has been shown to interact with ITGB3BP.[3]


  1. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. PMID 8034312. doi:10.1006/geno.1994.1193. 
  2. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma". 
  3. ^ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. PMC 100002. PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001. 

Further reading

  • Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2: S126–43. PMID 15608692. doi:10.1038/sj.cdd.4401533. 
  • Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. PMID 1310259. doi:10.1016/0092-8674(92)90478-U. 
  • Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE et al. (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.". Genes Dev. 6 (3): 329–44. PMID 1312497. doi:10.1101/gad.6.3.329. 
  • Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y et al. (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human.". Immunogenetics 41 (2–3): 83–90. PMID 7806300. doi:10.1007/BF00182317. 
  • Muscat GE, Mynett-Johnson L, Dowhan D, Downes M, Griggs R (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. PMC 307847. PMID 8127707. doi:10.1093/nar/22.4.583. 
  • Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell 85 (3): 403–14. PMID 8616895. doi:10.1016/S0092-8674(00)81118-6. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW et al. (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology 65 (4): 299–306. PMID 9143002. doi:10.1159/000127188. 
  • Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. PMID 9147069. doi:10.1023/A:1026481205135. 
  • Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. PMID 9150186. doi:10.1093/jnci/89.9.624. 
  • Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology 139 (11): 4476–82. PMID 9794455. doi:10.1210/en.139.11.4476. 
  • Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R et al. (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. PMID 11397877. doi:10.1210/jc.86.6.2721. 
  • Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH et al. (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene 20 (45): 6638–42. PMID 11641790. doi:10.1038/sj.onc.1204695. 
  • Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S et al. (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661. 
  • Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. PMID 12082103. doi:10.1074/jbc.M203572200. 
  • Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta 23 (8–9): 661–71. PMID 12361685. doi:10.1053/plac.2002.0855. 
  • Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S et al. (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. PMID 12444914. 
  • Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. PMID 12514092. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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