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RhoD

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Identifiers
SymbolsRHOD ; ARHD; RHOHP1; RHOM; Rho
External IDsOMIM605781 MGI108446 HomoloGene22409 GeneCards: RHOD Gene
RNA expression pattern
File:PBB GE RHOD 31846 at tn.png
File:PBB GE RHOD 209885 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2998411854
EnsemblENSG00000173156ENSMUSG00000041845
UniProtO00212P97348
RefSeq (mRNA)NM_001300886NM_007485
RefSeq (protein)NP_001287815NP_031511
Location (UCSC)Chr 11:
66.82 – 66.84 Mb
Chr 19:
4.43 – 4.44 Mb
PubMed search[1][2]

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOD.[2]

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[2]

Interactions

RhoD has been shown to interact with CNKSR1[3] and DIAPH2.[4]

References

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. ISSN 0962-8924. PMID 16949823. doi:10.1016/j.tcb.2006.08.006. 
  2. ^ a b "Entrez Gene: RHOD ras homolog gene family, member D". 
  3. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. (United States) 24 (4): 1736–46. ISSN 0270-7306. PMC 344169. PMID 14749388. doi:10.1128/MCB.24.4.1736-1746.2004. 
  4. ^ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. (England) 5 (3): 195–204. ISSN 1465-7392. PMID 12577064. doi:10.1038/ncb935. 

Further reading

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