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Open Access Articles- Top Results for Ro10-5824

Ro10-5824

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Ro10-5824
File:Ro10-5824 structure.png
Systematic (IUPAC) name
2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine
Clinical data
Identifiers
189744-46-5
PubChem CID 16759175
Chemical data
Formula C17H20N4
280.367 g/mol
 14pxY (what is this?)  (verify)

Ro10-5824 is a drug which acts as a dopamine receptor partial agonist selective for the D4 subtype, and has nootropic effects in animal studies.[1][2]


References

  1. ^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). "RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice". Neuropharmacology 44 (4): 473–81. PMID 12646284. doi:10.1016/S0028-3908(02)00412-4. 
  2. ^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells". The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307. PMID 17897483. doi:10.1017/S1461145707008061. 


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