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The rostral neuropore or anterior neuropore is a region corresponding to the opening of the embryonic neural tube in the anterior portion of the developing prosencephalon. The central nervous system develops from the neural tube, which initially starts as a plate of cells in the ectoderm and this is called the neural plate, the neural plate then undergoes folding and starts closing from the center of the developing fetus, this leads to two open ends, one situated cranially/rostrally and the other caudally. Bending of the neural plate
begins on day 22, and the cranial neuropore closes on day 24. giving rise to the lamina terminalis of the brain.
Failure to close
Failure of closure of the anterior neuropore during embryogenesis will lead to anencephaly, the failure of the brain and skull to develop.
Failure of closure of the posterior neuropore (caudal neuropore) during embryogenesis will lead to spina bifida.
- ^ Human Embryology, 4th edition, ISBN 978-0443-06811-9 PA
- ^ O'Rahilly R, Müller F. Bidirectional closure of the rostral neuropore in the human embryo].Am J Anat. 1989 Apr;184(4):259-68 PMID 2756902