The Itaipava São Paulo Indy 300 presented by Nestlé was an event in the IRL IndyCar Series, which opened the 2010 IndyCar Series season.
The event was announced on November 25, 2009, as the first championship event for the series outside of North America and Japan, and the first American open-wheel race in the country since the Rio 200 at Jacarepaguá in 2000. Due to a lengthy distance to travel from most team bases, the event promoters offer each team a six-figure sum of money, as well as paying for all expenses.
The circuit is located in the Santana district, birthplace of legendary Brazilian driver Ayrton Senna and Brazilian auto racing pioneer Chico Landi. The main straightaway of the track is along the Sambadrome of Anhembi and utilizes portions of the Marginal Tietê service drive. The Anhembi Convention Center will be used for support facilities and spectator attractions. Unlike many other circuits, the pit lane is not located around the start-finish line; it is instead positioned after turn four. The circuit is one of two IndyCar Series circuits (Baltimore the other) to have pit lanes not positioned at the start-finish line.
- 2010: Race shortened due to rain and two-hour time limit.
- 2011: Rain forced a postponement of the race after 15 laps. Race resumed on Monday and was shortened due to rain and two-hour time limit.