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SCN3A

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Identifiers
SymbolsSCN3A ; NAC3; Nav1.3
External IDsOMIM182391 MGI98249 HomoloGene56005 IUPHAR: 580 ChEMBL: 5163 GeneCards: SCN3A Gene
RNA expression pattern
File:PBB GE SCN3A 210432 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez632820269
EnsemblENSG00000153253ENSMUSG00000057182
UniProtQ9NY46A2ASI4
RefSeq (mRNA)NM_001081676NM_018732
RefSeq (protein)NP_001075145NP_061202
Location (UCSC)Chr 2:
165.94 – 166.06 Mb
Chr 2:
65.46 – 65.57 Mb
PubMed search[1][2]

Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the Nav1.3 gene.[1]

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

SCN3A is the only sodium channel transcript which is changed after nerve injury.

See also

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Further reading

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External links

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