Open Access Articles- Top Results for SCN3B


SymbolsSCN3B ; HSA243396; SCNB3
External IDsOMIM608214 MGI1918882 HomoloGene10176 ChEMBL: 5488 GeneCards: SCN3B Gene
RNA expression pattern
File:PBB GE SCN3B 204723 at tn.png
File:PBB GE SCN3B 204722 at tn.png
More reference expression data
RefSeq (mRNA)NM_001040151NM_001083917
RefSeq (protein)NP_001035241NP_001077386
Location (UCSC)Chr 11:
123.5 – 123.53 Mb
Chr 9:
40.27 – 40.29 Mb
PubMed search[1][2]

Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene.[1][2] Two alternatively spliced variants, encoding the same protein, have been identified.


Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. [2]

Clinical significance

Mutations in the gene are associated with abnormal cardiac electrophysiology.[3][4]

See also


  1. ^ Morgan K, Stevens EB, Shah B, Cox PJ, Dixon AK, Lee K, Pinnock RD, Hughes J, Richardson PJ, Mizuguchi K, Jackson AP (Apr 2000). "β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics". Proc Natl Acad Sci U S A 97 (5): 2308–13. PMC 15797. PMID 10688874. doi:10.1073/pnas.030362197. 
  2. ^ a b "Entrez Gene: SCN3B sodium channel, voltage-gated, type III, beta". 
  3. ^ Hakim P, Gurung IS, Pedersen TH, Thresher R, Brice N, Lawrence J, Grace AA, Huang CL (2008). "Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties". Prog. Biophys. Mol. Biol. 98 (2-3): 251–66. PMC 2764399. PMID 19351516. doi:10.1016/j.pbiomolbio.2009.01.005. 
  4. ^ Hakim P, Brice N, Thresher R, Lawrence J, Zhang Y, Jackson AP, Grace AA, Huang CL (January 2010). "Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties". Acta Physiol (Oxf) 198 (1): 47–59. PMID 19796257. doi:10.1111/j.1748-1716.2009.02048.x. 

Further reading


External links

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