Open Access Articles- Top Results for SCNN1B


SymbolsSCNN1B ; BESC1; ENaCb; ENaCbeta; SCNEB
External IDsOMIM600760 MGI104696 HomoloGene133555 IUPHAR: 739 ChEMBL: 1628483 GeneCards: SCNN1B Gene
RNA expression pattern
File:PBB GE SCNN1B 205464 at tn.png
More reference expression data
RefSeq (mRNA)NM_000336NM_001272023
RefSeq (protein)NP_000327NP_001258952
Location (UCSC)Chr 16:
23.29 – 23.39 Mb
Chr 7:
121.87 – 121.92 Mb
PubMed search[1][2]

Amiloride-sensitive sodium channel beta subunit is one of the three subunits that form the Epithelial sodium channel. In humans this protein is encoded by the SCNN1B gene.[1]

Gene and protein structure

In the human genome the gene encoding for the beta subunit of ENaC includes 13 exons. Exons 2-13 include the coding region of the gene. The location of the introns in all three genes coding for the three subunits is strictly conserved. The protein sequences of the three subunits show 26-30% sequence identity. [2]


SCNN1B has been shown to interact with WWP2[3][4] and NEDD4.[3][4][5]


  1. ^ "Entrez Gene: SCNN1B sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)". 
  2. ^ Saxena A, Hanukoglu I, Strautnieks SS, Thompson RJ, Gardiner RM, Hanukoglu A (Nov 1998). "Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.". Biochem Biophys Res Commun 252 (1): 208–13. PMID 9813171. doi:10.1006/bbrc.1998.9625. 
  3. ^ a b McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. 283 (3): F431–6. PMID 12167593. doi:10.1152/ajprenal.00080.2002. 
  4. ^ a b Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. PMID 11244092. doi:10.1074/jbc.C000906200. 
  5. ^ Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 Pt 3 (3): 503–9. PMC 1220784. PMID 10642508. doi:10.1042/0264-6021:3450503. 

Further reading


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