Open Access Articles- Top Results for SECISBP2


SymbolsSECISBP2 ; SBP2
External IDsOMIM607693 MGI1922670 HomoloGene11415 GeneCards: SECISBP2 Gene
RNA expression pattern
File:PBB GE SECISBP2 218265 at tn.png
More reference expression data
RefSeq (mRNA)NM_001282688NM_029279
RefSeq (protein)NP_001269617NP_083555
Location (UCSC)Chr 9:
91.93 – 91.97 Mb
Chr 13:
51.65 – 51.68 Mb
PubMed search[1][2]

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.[1][2]


The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.[2]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[2]

See also


  1. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. PMC 311072. PMID 11230166. doi:10.1101/gr.GR1547R. 
  2. ^ a b c "Entrez Gene: SECISBP2 SECIS binding protein 2". 

Further reading


Lua error in package.lua at line 80: module 'Module:Buffer' not found.