Adverts

Open Access Articles- Top Results for SGCG

SGCG

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSGCG ; A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; SCARMD2; SCG3; TYPE
External IDsOMIM608896 MGI1346524 HomoloGene194 GeneCards: SGCG Gene
RNA expression pattern
File:PBB GE SGCG 207302 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez644524053
EnsemblENSG00000102683ENSMUSG00000035296
UniProtQ13326P82348
RefSeq (mRNA)NM_000231NM_011892
RefSeq (protein)NP_000222NP_036022
Location (UCSC)Chr 13:
23.76 – 23.9 Mb
Chr 14:
61.22 – 61.26 Mb
PubMed search[1][2]

Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene.[1][2]

Function

Gamma-sarcoglycan is one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin, probably to provide a link between the membrane associated cytoskeleton and the extracellular matrix. Defects in the protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).[2]

Interactions

SGCG has been shown to interact with FLNC.[3][4]

References

  1. ^ Piccolo F, Jeanpierre M, Leturcq F, Dodé C, Azibi K, Toutain A et al. (March 1997). "A founder mutation in the gamma-sarcoglycan gene of gypsies possibly predating their migration out of India". Hum Mol Genet 5 (12): 2019–22. PMID 8968757. doi:10.1093/hmg/5.12.2019. 
  2. ^ a b "Entrez Gene: SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)". 
  3. ^ Guyon JR, Kudryashova E, Potts A, Dalkilic I, Brosius MA, Thompson TG et al. (October 2003). "Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans". Muscle Nerve 28 (4): 472–83. PMID 14506720. doi:10.1002/mus.10465. 
  4. ^ Thompson TG, Chan YM, Hack AA, Brosius M, Rajala M, Lidov HG et al. (January 2000). "Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein". J. Cell Biol. 148 (1): 115–26. PMC 3207142. PMID 10629222. doi:10.1083/jcb.148.1.115. 


Further reading

</dl>

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.