Open Access Articles- Top Results for SGK3


SymbolsSGK3 ; CISK; SGK2; SGKL
External IDsOMIM607591 MGI2182368 HomoloGene56582 IUPHAR: 1536 GeneCards: SGK3 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE SGK3 220038 at tn.png
More reference expression data
RefSeq (mRNA)NM_001033578NM_001037759
RefSeq (protein)NP_001028750NP_001032848
Location (UCSC)Chr 8:
67.58 – 67.77 Mb
Chr 1:
9.8 – 9.9 Mb
PubMed search[1][2]

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[1][2][3]


This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

In melanocytic cells SGK3 gene expression may be regulated by MITF.[4]


SGK3 has been shown to interact with GSK3B.[5]


  1. ^ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X et al. (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics 62 (1): 95–7. PMID 10585774. doi:10.1006/geno.1999.5969. 
  2. ^ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. PMC 1220630. PMID 10548550. doi:10.1042/0264-6021:3440189. 
  3. ^ a b "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 
  5. ^ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y et al. (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. PMID 12054501. doi:10.1016/S0006-291X(02)00349-2. 

Further reading


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