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Open Access Articles- Top Results for SIB-1553A

SIB-1553A

SIB-1553A
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IUPAC name
(R/S)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride
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191611-76-4 7pxY
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C13H19NOS
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β4 subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model.[1]

References

  1. ^ Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics 306 (1): 401–6. PMID 12721323. doi:10.1124/jpet.103.051912. 


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