Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.