Open Access Articles- Top Results for SIX1


SymbolsSIX1 ; BOS3; DFNA23; TIP39
External IDsOMIM601205 MGI102780 HomoloGene4360 GeneCards: SIX1 Gene
RNA expression pattern
File:PBB GE SIX1 205817 at tn.png
More reference expression data
RefSeq (mRNA)NM_005982NM_009189
RefSeq (protein)NP_005973NP_033215
Location (UCSC)Chr 14:
61.11 – 61.12 Mb
Chr 12:
73.04 – 73.05 Mb
PubMed search[1][2]

Homeobox protein SIX1 is a protein that in humans is encoded by the SIX1 gene.[1][2][3]

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][3]


SIX1 has been shown to interact with EYA1[4] and MDFI.[5]


  1. ^ Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (June 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics 33 (1): 140–2. PMID 8617500. doi:10.1006/geno.1996.0172. 
  2. ^ Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM Jr, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proc Natl Acad Sci U S A 101 (21): 8090–5. PMC 419562. PMID 15141091. doi:10.1073/pnas.0308475101. 
  3. ^ a b "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 
  4. ^ Buller, C; Xu X; Marquis V; Schwanke R; Xu P X (November 2001). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Hum. Mol. Genet. (England) 10 (24): 2775–81. ISSN 0964-6906. PMID 11734542. doi:10.1093/hmg/10.24.2775. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 

Further reading


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