Open Access Articles- Top Results for SLAMF1


SymbolsSLAMF1 ; CD150; CDw150; SLAM
External IDsOMIM603492 MGI1351314 HomoloGene48162 GeneCards: SLAMF1 Gene
RNA expression pattern
File:PBB GE SLAMF1 206181 at tn.png
More reference expression data
RefSeq (mRNA)NM_003037NM_013730
RefSeq (protein)NP_003028NP_038758
Location (UCSC)Chr 1:
160.58 – 160.62 Mb
Chr 1:
171.77 – 171.8 Mb
PubMed search[1][2]

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.[1][2] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family.


SLAMF1 has been shown to interact with PTPN11,[3][4] SH2D1A[3][5] and SH2D1B.[4]


  1. ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature 376 (6537): 260–3. PMID 7617038. doi:10.1038/376260a0. 
  2. ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1". 
  3. ^ a b Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood 99 (3): 957–65. PMID 11806999. doi:10.1182/blood.V99.3.957. 
  4. ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S et al. (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. PMC 125701. PMID 11689425. doi:10.1093/emboj/20.21.5840. 
  5. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O et al. (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. PMID 11477068. doi:10.1074/jbc.M101305200. 

Further reading


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