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SLC10A1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSLC10A1 ; NTCP
External IDsOMIM182396 MGI97379 HomoloGene31126 IUPHAR: 959 ChEMBL: 5287 GeneCards: SLC10A1 Gene
RNA expression pattern
File:PBB GE SLC10A1 207185 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez655420493
EnsemblENSG00000100652ENSMUSG00000021135
UniProtQ14973O08705
RefSeq (mRNA)NM_003049NM_001177561
RefSeq (protein)NP_003040NP_001171032
Location (UCSC)Chr 14:
69.78 – 69.8 Mb
Chr 12:
80.95 – 80.97 Mb
PubMed search[1][2]

Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[1][2]

Function

Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2), and the other being found in the basolateral membranes of hepatocytes (SLC10A1; this protein).[1]

NTCP is a cell surface receptor necessary for the entry of Hepatitis B and Hepatitis D Virus.[3]

See also

References

Further reading

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