Open Access Articles- Top Results for SLC11A1


External IDsOMIM600266 MGI1345275 HomoloGene73884 IUPHAR: 966 GeneCards: SLC11A1 Gene
RNA expression pattern
File:PBB GE SLC11A1 210423 s at tn.png
File:PBB GE SLC11A1 210422 x at tn.png
File:PBB GE SLC11A1 217473 x at tn.png
More reference expression data
RefSeq (mRNA)NM_000578NM_013612
RefSeq (protein)NP_000569NP_038640
Location (UCSC)Chr 2:
219.25 – 219.26 Mb
Chr 1:
74.38 – 74.39 Mb
PubMed search[1][2]

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[1][2][3]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]

See also


  1. ^ Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (Dec 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". J Exp Med 180 (5): 1741–52. PMC 2191750. PMID 7964458. doi:10.1084/jem.180.5.1741. 
  2. ^ Kishi F (Dec 1994). "Isolation and characterization of human Nramp cDNA". Biochem. Biophys. Res. Commun. 204 (3): 1074–80. PMID 7980580. doi:10.1006/bbrc.1994.2572. 
  3. ^ a b "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1". 
  4. ^ Teras, IuKh.; Ryĭgas, EM.; Kazakova, II.; Ranne, KhP.; Trapido, LE. (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases].". Ter Arkh 52 (3): 123–5. PMID 7385031. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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