Open Access Articles- Top Results for SLC12A6


SymbolsSLC12A6 ; ACCPN; KCC3; KCC3A; KCC3B
External IDsOMIM604878 MGI2135960 HomoloGene21069 IUPHAR: 973 GeneCards: SLC12A6 Gene
RNA expression pattern
File:PBB GE SLC12A6 220740 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001042494NM_133648
RefSeq (protein)NP_001035959NP_598409
Location (UCSC)Chr 15:
34.53 – 34.63 Mb
Chr 2:
112.27 – 112.36 Mb
PubMed search[1][2]

Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.[1][2][3]

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms, the most important ones being KCC3a and KCC3b. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.[3]

See also


  1. ^ Hiki K, D'Andrea RJ, Furze J, Crawford J, Woollatt E, Sutherland GR, Vadas MA, Gamble JR (May 1999). "Cloning, characterization, and chromosomal location of a novel human K+-Cl cotransporter". J Biol Chem 274 (15): 10661–7. PMID 10187864. doi:10.1074/jbc.274.15.10661. 
  2. ^ Mount DB, Mercado A, Song L, Xu J, George AL Jr, Delpire E, Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem 274 (23): 16355–62. PMID 10347194. doi:10.1074/jbc.274.23.16355. 
  3. ^ a b "Entrez Gene: SLC12A6 solute carrier family 12 (potassium/chloride transporters), member 6". 

External links

Further reading

  • Race JE, Makhlouf FN, Logue PJ et al. (2000). "Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.". Am. J. Physiol. 277 (6 Pt 1): C1210–9. PMID 10600773. 
  • Casula S, Shmukler BE, Wilhelm S et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.". J. Biol. Chem. 276 (45): 41870–8. PMID 11551954. doi:10.1074/jbc.M107155200. 
  • Howard HC, Mount DB, Rochefort D et al. (2002). "The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum.". Nat. Genet. 32 (3): 384–92. PMID 12368912. doi:10.1038/ng1002. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Bräuer M, Frei E, Claes L et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. PMID 12637262. doi:10.1152/ajpcell.00289.2002. 
  • Bergeron MJ, Gagnon E, Wallendorff B et al. (2003). "Ammonium transport and pH regulation by K+-Cl cotransporters.". Am. J. Physiol. Renal Physiol. 285 (1): F68–78. PMID 12657561. doi:10.1152/ajprenal.00032.2003. 
  • Shen MR, Lin AC, Hsu YM et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.". J. Biol. Chem. 279 (38): 40017–25. PMID 15262997. doi:10.1074/jbc.M406706200. 
  • Mercado A, Vázquez N, Song L et al. (2005). "NH2-terminal heterogeneity in the KCC3 K+-Cl cotransporter.". Am. J. Physiol. Renal Physiol. 289 (6): F1246–61. PMID 16048901. doi:10.1152/ajprenal.00464.2004. 
  • Uyanik G, Elcioglu N, Penzien J et al. (2006). "Novel truncating and missense mutations of the KCC3 gene associated with Andermann syndrome.". Neurology 66 (7): 1044–8. PMID 16606917. doi:10.1212/01.wnl.0000204181.31175.8b. 
  • Hsu YM, Chou CY, Chen HH et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.". J. Cell. Physiol. 210 (3): 626–36. PMID 17133354. doi:10.1002/jcp.20859. 
  • Salin-Cantegrel A, Rivière JB, Dupré N et al. (2007). "Distal truncation of KCC3 in non-French Canadian HMSN/ACC families.". Neurology 69 (13): 1350–5. PMID 17893295. doi:10.1212/01.wnl.0000291779.35643.15. 
  • Hsu YM, Chen YF, Chou CY et al. (2007). "KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition.". Cancer Res. 67 (22): 11064–73. PMID 18006853. doi:10.1158/0008-5472.CAN-07-2443. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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