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SLC13A3

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Identifiers
SymbolsSLC13A3 ; NADC3; SDCT2
External IDsOMIM606411 MGI2149635 HomoloGene11266 IUPHAR: 979 GeneCards: SLC13A3 Gene
RNA expression pattern
File:PBB GE SLC13A3 205243 at tn.png
File:PBB GE SLC13A3 205244 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez64849114644
EnsemblENSG00000158296ENSMUSG00000018459
UniProtQ8WWT9Q91Y63
RefSeq (mRNA)NM_001011554NM_054055
RefSeq (protein)NP_001011554NP_473396
Location (UCSC)Chr 20:
45.19 – 45.3 Mb
Chr 2:
165.41 – 165.47 Mb
PubMed search[1][2]

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.[1][2][3]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.[3]

See also

References

  1. ^ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol 278 (5): C1019–30. PMID 10794676. 
  2. ^ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther 295 (1): 392–403. PMID 10992006. 
  3. ^ a b "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3". 

Further reading

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