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SLC17A8

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Identifiers
SymbolsSLC17A8 ; DFNA25; VGLUT3
External IDsOMIM607557 MGI3039629 HomoloGene13584 IUPHAR: 1009 GeneCards: SLC17A8 Gene
Orthologs
SpeciesHumanMouse
Entrez246213216227
EnsemblENSG00000179520ENSMUSG00000019935
UniProtQ8NDX2Q8BFU8
RefSeq (mRNA)NM_001145288NM_182959
RefSeq (protein)NP_001138760NP_892004
Location (UCSC)Chr 12:
100.75 – 100.82 Mb
Chr 10:
89.57 – 89.62 Mb
PubMed search[1][2]

Solute carrier family 17 member 8 (SLC17A8) also known as the vesicular glutamate transporter 3 (VGluT3) is a protein that in humans is encoded by the SLC17A8 gene.[1]

Function

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[1]

Clinical significance

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[2][3]

References

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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