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SLC22A2

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Identifiers
SymbolsSLC22A2 ; OCT2
External IDsOMIM602608 MGI1335072 HomoloGene68293 IUPHAR: 1020 ChEMBL: 1743122 GeneCards: SLC22A2 Gene
RNA expression pattern
File:PBB GE SLC22A2 207429 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez658220518
EnsemblENSG00000112499ENSMUSG00000040966
UniProtO15244O70577
RefSeq (mRNA)NM_003058NM_013667
RefSeq (protein)NP_003049NP_038695
Location (UCSC)Chr 6:
160.59 – 160.7 Mb
Chr 17:
12.58 – 12.63 Mb
PubMed search[1][2]

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[2]

See also

References

  1. Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3-4): 198–200. PMID 9605850. doi:10.1159/000134720. 
  2. 2.0 2.1 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2". 

Further reading

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