Journals

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Identifiers
Symbols	SLC25A12 ; AGC1; ARALAR
External IDs	OMIM: 603667 MGI: 1926080 HomoloGene: 48235 IUPHAR: 1054 GeneCards: SLC25A12 Gene
Gene ontology Molecular function • L-glutamate transmembrane transporter activity • calcium ion binding • L-aspartate transmembrane transporter activity Cellular component • mitochondrion • mitochondrial inner membrane • integral component of membrane Biological process • carbohydrate metabolic process • glucose metabolic process • gluconeogenesis • aspartate transport • L-glutamate transport • malate-aspartate shuttle • small molecule metabolic process • response to calcium ion • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SLC25A12 203340 s at tn.png
File:PBB GE SLC25A12 203339 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8604	78830
Ensembl	ENSG00000115840	ENSMUSG00000027010
UniProt	O75746	Q8BH59
RefSeq (mRNA)	NM_003705	NM_172436
RefSeq (protein)	NP_003696	NP_766024
Location (UCSC)	Chr 2: 172.64 – 172.86 Mb	Chr 2: 71.27 – 71.37 Mb
PubMed search	[1]	[2]

Calcium-binding mitochondrial carrier protein Aralar1 is a protein that in humans is encoded by the SLC25A12 gene.

See also

• Solute carrier family

Further reading

• Kobayashi K; Sinasac DS; Iijima M et al. (1999). "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein". Nat. Genet. 22 (2): 159–63. PMID 10369257. doi:10.1038/9667. 
• Sanz R; del Arco A; Ayuso C et al. (2000). "Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization". Cytogenet. Cell Genet. 89 (3–4): 143–4. PMID 10965105. doi:10.1159/000015595. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
• Ramoz N; Reichert JG; Smith CJ et al. (2004). "Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism". The American Journal of Psychiatry 161 (4): 662–9. PMID 15056512. doi:10.1176/appi.ajp.161.4.662. 
• Rubi B; del Arco A; Bartley C et al. (2005). "The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells". J. Biol. Chem. 279 (53): 55659–66. PMID 15494407. doi:10.1074/jbc.M409303200. 
• Rabionet R; McCauley JL; Jaworski JM et al. (2006). "Lack of association between autism and SLC25A12". The American Journal of Psychiatry 163 (5): 929–31. PMID 16648338. doi:10.1176/appi.ajp.163.5.929. 
• Ewing RM; Chu P; Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134. 
• Hong CJ; Liou YJ; Liao DL et al. (2007). "Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (7): 1510–3. PMID 17693006. doi:10.1016/j.pnpbp.2007.07.010. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.