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SLC25A3

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Identifiers
SymbolsSLC25A3 ; PHC; PTP
External IDsOMIM600370 MGI1353498 HomoloGene37649 IUPHAR: 1061 GeneCards: SLC25A3 Gene
Orthologs
SpeciesHumanMouse
Entrez525018674
EnsemblENSG00000075415ENSMUSG00000061904
UniProtQ00325Q8VEM8
RefSeq (mRNA)NM_002635NM_133668
RefSeq (protein)NP_002626NP_598429
Location (UCSC)Chr 12:
98.99 – 99 Mb
Chr 10:
91.12 – 91.12 Mb
PubMed search[1][2]

Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene.[1][2]

The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.[2]

See also

References

  1. Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet 93 (5): 600–2. PMID 8168843. doi:10.1007/bf00202832. 
  2. 2.0 2.1 "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3". 

Further reading

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