Open Access Articles- Top Results for SLC2A9


External IDsOMIM606142 MGI2152844 HomoloGene69290 IUPHAR: 882 GeneCards: SLC2A9 Gene
RNA expression pattern
File:PBB GE SLC2A9 219991 at tn.png
More reference expression data
RefSeq (mRNA)NM_001001290NM_001012363
RefSeq (protein)NP_001001290NP_001012363
Location (UCSC)Chr 4:
9.77 – 10.06 Mb
Chr 5:
38.35 – 38.5 Mb
PubMed search[1][2]

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[1][2][3]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.[4][5][6]

See also


  1. ^ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics 66 (2): 217–20. PMID 10860667. doi:10.1006/geno.2000.6195. 
  2. ^ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol 24 (5-6): 455–63. PMID 17710649. doi:10.1080/09687680701298143. 
  3. ^ a b "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9". 
  4. ^ Vitart V, Rudan I, Hayward C et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics 40 (4): 437–42. PMID 18327257. doi:10.1038/ng.106. 
  5. ^ Döring A, Gieger C, Mehta D et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics 40 (4): 430–6. PMID 18327256. doi:10.1038/ng.107. 
  6. ^ Hollingworth P, Sweet R, Sims R et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry 17: 1316–1327. doi:10.1038/mp.2011.125. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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