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SLC39A1
| Identifiers | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbols | SLC39A1 ; ZIP1; ZIRTL | ||||||||||||
| External IDs | OMIM: 604740 MGI: 1353474 HomoloGene: 40906 IUPHAR: 1180 GeneCards: SLC39A1 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
| File:PBB GE SLC39A1 217778 at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 27173 | 30791 | |||||||||||
| Ensembl | ENSG00000143570 | ENSMUSG00000052310 | |||||||||||
| UniProt | Q9NY26 | Q9QZ03 | |||||||||||
| RefSeq (mRNA) | NM_001271957 | NM_013901 | |||||||||||
| RefSeq (protein) | NP_001258886 | NP_038929 | |||||||||||
| Location (UCSC) | Chr 1: 153.93 – 153.94 Mb | Chr 3: 90.25 – 90.25 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1] [2][3]
The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]
See also
References
- ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80. PMID 10610721. doi:10.1006/geno.1999.5993.
- ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4. PMID 10681536. doi:10.1074/jbc.275.8.5560.
- ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
- ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17. PMC 1481516. PMID 16700911. doi:10.1186/1476-4598-5-17.
Further reading
- Lai CH, Chou CY, Ch'ang LY et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMC 310876. PMID 10810093. doi:10.1101/gr.10.5.703.
- Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.". J. Biol. Chem. 276 (25): 22258–64. PMID 11301334. doi:10.1074/jbc.M101772200.
- Milon B, Dhermy D, Pountney D et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells.". FEBS Lett. 507 (3): 241–6. PMID 11696349. doi:10.1016/S0014-5793(01)02950-7.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Franklin RB, Ma J, Zou J et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.". J. Inorg. Biochem. 96 (2–3): 435–42. PMID 12888280. doi:10.1016/S0162-0134(03)00249-6.
- Dufner-Beattie J, Langmade SJ, Wang F et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. PMID 14525987. doi:10.1074/jbc.M304163200.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Franklin RB, Feng P, Milon B et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer 4: 32. PMC 1243239. PMID 16153295. doi:10.1186/1476-4598-4-32.
- Tang Z, Sahu SN, Khadeer MA et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone 38 (2): 181–98. PMID 16203195. doi:10.1016/j.bone.2005.08.010.
- Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
- Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. PMID 17635580. doi:10.1111/j.1742-4658.2007.05933.x.
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