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SLC39A1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSLC39A1 ; ZIP1; ZIRTL
External IDsOMIM604740 MGI1353474 HomoloGene40906 IUPHAR: 1180 GeneCards: SLC39A1 Gene
RNA expression pattern
File:PBB GE SLC39A1 217778 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2717330791
EnsemblENSG00000143570ENSMUSG00000052310
UniProtQ9NY26Q9QZ03
RefSeq (mRNA)NM_001271957NM_013901
RefSeq (protein)NP_001258886NP_038929
Location (UCSC)Chr 1:
153.93 – 153.94 Mb
Chr 3:
90.25 – 90.25 Mb
PubMed search[1][2]

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1] [2][3]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]


See also

References

  1. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80. PMID 10610721. doi:10.1006/geno.1999.5993. 
  2. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4. PMID 10681536. doi:10.1074/jbc.275.8.5560. 
  3. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1". 
  4. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17. PMC 1481516. PMID 16700911. doi:10.1186/1476-4598-5-17. 

Further reading

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