Open Access Articles- Top Results for SLC41A3


SymbolsSLC41A3 ; SLC41A1-L2
External IDsOMIM610803 HomoloGene23052 IUPHAR: 1197 GeneCards: SLC41A3 Gene
RefSeq (mRNA)NM_001008485NM_001037493
RefSeq (protein)NP_001008485NP_001032570
Location (UCSC)Chr 3:
125.73 – 125.82 Mb
Chr 6:
90.6 – 90.65 Mb
PubMed search[1][2]

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.[1]

Model organisms

Model organisms have been used in the study of SLC41A3 function. A conditional knockout mouse line, called Slc41a3tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty six tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutants displayed abnormal locomotor coordination.[4]


  1. ^ "Entrez Gene: Solute carrier family 41, member 3". Retrieved 2011-09-28. 
  2. ^ "Salmonella infection data for Slc41a3". Wellcome Trust Sanger Institute. 
  3. ^ "Citrobacter infection data for Slc41a3". Wellcome Trust Sanger Institute. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. PMC 3572410. PMID 21677750. doi:10.1038/nature10163.  edit
  9. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  10. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. PMC 3218837. PMID 21722353. doi:10.1186/gb-2011-12-6-224. 

Further reading

  • Wabakken, T.; Rian, E.; Kveine, M.; Aasheim, H. C. (2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications 306 (3): 718–724. PMID 12810078. doi:10.1016/S0006-291X(03)01030-1.  edit

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