Open Access Articles- Top Results for SLC4A5


SymbolsSLC4A5 ; NBC4
External IDsOMIM606757 MGI2443220 HomoloGene31125 IUPHAR: 909 GeneCards: SLC4A5 Gene
RNA expression pattern
File:PBB GE SLC4A5 221723 s at tn.png
More reference expression data
RefSeq (mRNA)NM_021196NM_001166067
RefSeq (protein)NP_067019NP_001159539
Location (UCSC)Chr 2:
74.44 – 74.57 Mb
Chr 6:
83.22 – 83.3 Mb
PubMed search[1][2]

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.[1][2][3]


This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

Clinical significance

This human gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status.[4]

See also


  1. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Nov 2000). "Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family". Biochim Biophys Acta 1493 (1–2): 215–8. PMID 10978526. doi:10.1016/S0167-4781(00)00149-4. 
  2. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Mar 2001). "Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization". IUBMB Life 50 (1): 13–9. PMID 11087115. doi:10.1080/15216540050176539. 
  3. ^ a b "Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate cotransporter, member 5". 
  4. ^ Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T et al. (March 2012). "Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis". Hum. Mol. Genet. 21 (5): 1025–36. PMID 22082831. doi:10.1093/hmg/ddr533. 

Further reading

  • Soleimani M, Burnham CE (2002). "Na+:HCO(3-) cotransporters (NBC): cloning and characterization". J. Membr. Biol. 183 (2): 71–84. PMID 11562789. doi:10.1007/s00232-001-0055-8. 
  • Hunt SC, Xin Y, Wu LL, Cawthon RM, Coon H, Hasstedt SJ et al. (2006). "Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures". Hypertension 47 (3): 532–6. PMID 16365189. doi:10.1161/01.HYP.0000196949.26088.3c. 
  • Xu J, Wang Z, Barone S, Petrovic M, Amlal H, Conforti L et al. (2003). "Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant". Am. J. Physiol. Renal Physiol. 284 (1): F41–50. PMID 12388414. doi:10.1152/ajprenal.00055.2002 (inactive 2015-01-01). 
  • Pushkin A, Abuladze N, Newman D, Tatishchev S, Kurtz I (2002). "Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued)". Cytogenet. Cell Genet. 95 (3–4): 163–8. PMID 12063394. doi:10.1159/000059340. 
  • Sassani P, Pushkin A, Gross E, Gomer A, Abuladze N, Dukkipati R et al. (2002). "Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter". Am. J. Physiol., Cell Physiol. 282 (2): C408–16. PMID 11788353. doi:10.1152/ajpcell.00409.2001 (inactive 2015-01-01). 

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