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SLC5A4
| Identifiers | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbols | SLC5A4 ; DJ90G24.4; SAAT1; SGLT3 | ||||||||||||
| External IDs | MGI: 1927848 HomoloGene: 8591 IUPHAR: 917 ChEMBL: 1770047 GeneCards: SLC5A4 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6527 | 64452 | |||||||||||
| Ensembl | ENSG00000100191 | ENSMUSG00000020229 | |||||||||||
| UniProt | Q9NY91 | Q9ET37 | |||||||||||
| RefSeq (mRNA) | NM_014227 | NM_133184 | |||||||||||
| RefSeq (protein) | NP_055042 | NP_573447 | |||||||||||
| Location (UCSC) | Chr 22: 32.61 – 32.65 Mb | Chr 10: 76.15 – 76.19 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.[1][2][3]
References
- ^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
- ^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2914–9. PMC 19669. PMID 9501190. doi:10.1073/pnas.95.6.2914.
- ^ Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Lett. 529 (1): 73–7. PMID 12354616. doi:10.1016/S0014-5793(02)03184-8.
Further reading
- Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology 53 (1): 1–8. PMID 16319503. doi:10.1159/000089915.
- Blaya C, Salum GA, Lima MS et al. (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis.". Behavioral and Brain Functions 3: 41. PMC 1994953. PMID 17705872. doi:10.1186/1744-9081-3-41.
- Diez-Sampedro A, Hirayama BA, Osswald C et al. (2003). "A glucose sensor hiding in a family of transporters.". Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11753–8. PMC 208830. PMID 13130073. doi:10.1073/pnas.1733027100.
- Fairchild TJ (2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". J. Appl. Physiol. 104 (1): 315; author reply 316. PMID 18198291. doi:10.1152/japplphysiol.00793.2007.
- Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031.
- Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Mol. Pharmacol. 71 (2): 628–34. PMID 17110502. doi:10.1124/mol.106.030288.
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