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SLC5A8
| Identifiers | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbols | SLC5A8 ; AIT; SMCT; SMCT1 | ||||||||||||
| External IDs | OMIM: 608044 MGI: 2384916 HomoloGene: 64832 IUPHAR: 922 GeneCards: SLC5A8 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
| File:PBB GE SLC5A8 gnf1h02682 at tn.png | |||||||||||||
| File:PBB GE SLC5A8 gnf1h06296 at tn.png | |||||||||||||
| File:PBB GE SLC5A8 gnf1h06297 s at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 160728 | 216225 | |||||||||||
| Ensembl | ENSG00000256870 | ENSMUSG00000020062 | |||||||||||
| UniProt | Q8N695 | Q8BYF6 | |||||||||||
| RefSeq (mRNA) | NM_145913 | NM_145423 | |||||||||||
| RefSeq (protein) | NP_666018 | NP_663398 | |||||||||||
| Location (UCSC) | Chr 12: 101.55 – 101.6 Mb | Chr 10: 88.89 – 88.93 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.[1][2][3]
See also
References
- ^ Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab 87 (7): 3500–3. PMID 12107270. doi:10.1210/jc.87.7.3500.
- ^ Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A 100 (14): 8412–7. PMC 166243. PMID 12829793. doi:10.1073/pnas.1430846100.
- ^ "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".
Further reading
- Gupta N, Martin PM, Prasad PD, Ganapathy V (2006). "SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter". Life Sci. 78 (21): 2419–25. PMID 16375929. doi:10.1016/j.lfs.2005.10.028.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Miyauchi S, Gopal E, Fei YJ, Ganapathy V (2004). "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids". J. Biol. Chem. 279 (14): 13293–6. PMID 14966140. doi:10.1074/jbc.C400059200.
- Lacroix L, Pourcher T, Magnon C et al. (2004). "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters". J. Clin. Endocrinol. Metab. 89 (3): 1423–8. PMID 15001644. doi:10.1210/jc.2003-030542.
- Hong C, Maunakea A, Jun P et al. (2005). "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8". Cancer Res. 65 (9): 3617–23. PMID 15867356. doi:10.1158/0008-5472.CAN-05-0048.
- Paroder V, Spencer SR, Paroder M et al. (2006). "Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7270–5. PMC 1456061. PMID 16670197. doi:10.1073/pnas.0602365103.
- Hu S, Liu D, Tufano RP et al. (2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer". Int. J. Cancer 119 (10): 2322–9. PMID 16858683. doi:10.1002/ijc.22110.
- Gopal E, Miyauchi S, Martin PM et al. (2007). "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract". Pharm. Res. 24 (3): 575–84. PMID 17245649. doi:10.1007/s11095-006-9176-1.
- Coady MJ, Wallendorff B, Bourgeois F et al. (2007). "Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1". Biophys. J. 93 (7): 2325–31. PMC 1965447. PMID 17526579. doi:10.1529/biophysj.107.108555.
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