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Open Access Articles- Top Results for SLC7A11

SLC7A11

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Identifiers
SymbolsSLC7A11 ; CCBR1; xCT
External IDsOMIM607933 MGI1347355 HomoloGene22684 IUPHAR: 902 ChEMBL: 1075149 GeneCards: SLC7A11 Gene
RNA expression pattern
File:PBB GE SLC7A11 209921 at tn.png
File:PBB GE SLC7A11 207528 s at tn.png
File:PBB GE SLC7A11 217678 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2365726570
EnsemblENSG00000151012ENSMUSG00000027737
UniProtQ9UPY5Q9WTR6
RefSeq (mRNA)NM_014331NM_011990
RefSeq (protein)NP_055146NP_036120
Location (UCSC)Chr 4:
139.09 – 139.16 Mb
Chr 3:
50.36 – 50.44 Mb
PubMed search[1][2]

Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene.[1][2][3]

Function

SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM][3] SLC7A11 has also been termed 'xCT', especially in older literature.

Clinical significance

Recently, SLC7A11 has been shown to be involved in the cellular import of dimethylarsino-cysteine, an active metabolite of darinaparsin, an arsenic-based glutathion S-conjugate, in cancer cells.[4]

See also

References

  1. ^ Sato H, Tamba M, Ishii T, Bannai S (May 1999). "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins". J Biol Chem 274 (17): 11455–8. PMID 10206947. doi:10.1074/jbc.274.17.11455. 
  2. ^ Wang H, Tamba M, Kimata M, Sakamoto K, Bannai S, Sato H (May 2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem Biophys Res Commun 305 (3): 611–8. PMID 12763038. doi:10.1016/S0006-291X(03)00808-8. 
  3. ^ a b "Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11". 
  4. ^ Garnier N, Redstone GG, Dahabieh MS, Nichol JN, del Rincon SV, Gu Y, Bohle DS, Sun Y, Conklin DS, Mann KK, Miller WH (2014). "The novel arsenical darinaparsin is transported by cystine importing systems". Mol. Pharmacol. 85 (4): 576–85. PMID 24431147. doi:10.1124/mol.113.089433. 

Further reading

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