Open Access Articles- Top Results for SLC9A8


SymbolsSLC9A8 ; NHE-8; NHE8
External IDsOMIM612730 MGI1924281 HomoloGene75041 IUPHAR: 955 GeneCards: SLC9A8 Gene
RNA expression pattern
File:PBB GE SLC9A8 212947 at tn.png
File:PBB GE SLC9A8 gnf1h01982 at tn.png
More reference expression data
RefSeq (mRNA)NM_001260491NM_148929
RefSeq (protein)NP_001247420NP_683731
Location (UCSC)Chr 20:
48.43 – 48.51 Mb
Chr 2:
167.42 – 167.48 Mb
PubMed search[1][2]

Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.[1][2]

Model organisms

Model organisms have been used in the study of SLC9A8 function. A conditional knockout mouse line, called Slc9a8tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty one tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant animals had abnormal retinal morphology and pigmentation.[4]

See also


  1. ^ Goyal S, Vanden Heuvel G, Aronson PS (Jan 2003). "Renal expression of novel Na+/H+ exchanger isoform NHE8". Am J Physiol Renal Physiol 284 (3): F467–73. PMID 12409279. doi:10.1152/ajprenal.00352.2002. 
  2. ^ "Entrez Gene: SLC9A8 solute carrier family 9 (sodium/hydrogen exchanger), member 8". 
  3. ^ "Eye morphology data for Slc9a8". Wellcome Trust Sanger Institute. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. PMC 3572410. PMID 21677750. doi:10.1038/nature10163.  edit
  9. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  10. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. PMC 3218837. PMID 21722353. doi:10.1186/gb-2011-12-6-224. 

Further reading


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