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Open Access Articles- Top Results for SLCO2A1

SLCO2A1

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Identifiers
SymbolsSLCO2A1 ; MATR1; OATP2A1; PGT; PHOAR2; SLC21A2
External IDsOMIM601460 HomoloGene38077 IUPHAR: 1223 GeneCards: SLCO2A1 Gene
Orthologs
SpeciesHumanMouse
Entrez657824059
EnsemblENSG00000174640ENSMUSG00000032548
UniProtQ92959Q9EPT5
RefSeq (mRNA)NM_005630NM_033314
RefSeq (protein)NP_005621NP_201571
Location (UCSC)Chr 3:
133.65 – 133.77 Mb
Chr 9:
103.01 – 103.09 Mb
PubMed search[1][2]

Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[1]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[1]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[2]

References

  1. ^ a b "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30. 
  2. ^ Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (December 2011). "Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy". Am J Hum Genet 90 (1): 125–32. PMID 22197487. doi:10.1016/j.ajhg.2011.11.019. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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