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Open Access Articles- Top Results for SNAP-94847

SNAP-94847

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SNAP-94847
File:SNAP-94847 structure.png
Systematic (IUPAC) name
N-(3-[1-([4-(3,4-difluorophenoxy)phenyl]methyl)(4-piperidyl)]-4-methylphenyl)-2-methylpropanamide
Clinical data
Identifiers
Chemical data
Formula C29H32F2N2O2
478.572
 14pxY (what is this?)  (verify)

SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects,[1][2] and also reduces food consumption suggesting a possible anorectic effect.[3]



References

  1. ^ David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (April 2007). "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics 321 (1): 237–48. PMID 17237257. doi:10.1124/jpet.106.109678. 
  2. ^ Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA (February 2009). "The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents". Behavioural Brain Research 197 (2): 284–91. PMID 18793675. doi:10.1016/j.bbr.2008.08.026. 
  3. ^ Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y (July 2009). "Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats". Psychopharmacology 205 (1): 129–40. PMC 3143407. PMID 19340414. doi:10.1007/s00213-009-1523-6. 

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