SOX1 (for Sex determining region Y-box 1) is a transcription factor in the Sox protein family. SOX1 expression is restricted to neuroectoderm in the tetrapod embryo. SOX1 is involved in early central nervous system development, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. SOX1 is expressed particularly in the ventral striatum, and Sox1-deficient mice have altered striatum development, leading e.g. to epilepsy.
- ^ a b Guth SI, Wegner M (October 2008). "Having it both ways: Sox protein function between conservation and innovation". Cell. Mol. Life Sci. 65 (19): 3000–18. PMID 18516494. doi:10.1007/s00018-008-8138-7.
- ^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006). "Expression of Sox1 during Xenopus early embryogenesis". Biochem. Biophys. Res. Commun. 351 (1): 287–93. PMID 17056008. doi:10.1016/j.bbrc.2006.10.040.
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